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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: JAK3 All Species: 14.85
Human Site: T8 Identified Species: 32.67
UniProt: P52333 Number Species: 10
    Phosphosite Substitution
    Charge Score: -0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P52333 NP_000206.2 1124 125099 T8 M A P P S E E T P L I P Q R S
Chimpanzee Pan troglodytes Q5IS37 825 92786
Rhesus Macaque Macaca mulatta XP_001115037 954 105707
Dog Lupus familis XP_852473 1103 122784 T8 M A P P S E E T P L I P Q R S
Cat Felis silvestris
Mouse Mus musculus Q62137 1100 122623 T8 M A P P S E E T P L I P Q R S
Rat Rattus norvegicus Q63272 1100 122542 T8 M A P P S E E T P L I S Q R S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505937 950 110363
Chicken Gallus gallus Q75R65 1129 129828 G21 T A T V H Q N G D I L G N T S
Frog Xenopus laevis NP_001085288 1129 130564 T12 M M T E I D R T T T P P V H S
Zebra Danio Brachydanio rerio O12990 1153 132463 C14 M D L G R Q L C V K M K K Q R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q24592 1177 135043 R10 L A N G G E D R M D D S S S G
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 20.5 83 88.6 N.A. 82.3 80 N.A. 42.7 50.1 48.7 39 N.A. 22.6 N.A. N.A. N.A.
Protein Similarity: 100 35.9 83.3 92 N.A. 87.9 86.3 N.A. 59 68.1 66.8 57.3 N.A. 40.7 N.A. N.A. N.A.
P-Site Identity: 100 0 0 100 N.A. 100 93.3 N.A. 0 13.3 26.6 6.6 N.A. 13.3 N.A. N.A. N.A.
P-Site Similarity: 100 0 0 100 N.A. 100 93.3 N.A. 0 33.3 33.3 33.3 N.A. 26.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 55 0 0 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 10 0 0 0 0 0 0 0 % C
% Asp: 0 10 0 0 0 10 10 0 10 10 10 0 0 0 0 % D
% Glu: 0 0 0 10 0 46 37 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 19 10 0 0 10 0 0 0 10 0 0 10 % G
% His: 0 0 0 0 10 0 0 0 0 0 0 0 0 10 0 % H
% Ile: 0 0 0 0 10 0 0 0 0 10 37 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 10 0 10 10 0 0 % K
% Leu: 10 0 10 0 0 0 10 0 0 37 10 0 0 0 0 % L
% Met: 55 10 0 0 0 0 0 0 10 0 10 0 0 0 0 % M
% Asn: 0 0 10 0 0 0 10 0 0 0 0 0 10 0 0 % N
% Pro: 0 0 37 37 0 0 0 0 37 0 10 37 0 0 0 % P
% Gln: 0 0 0 0 0 19 0 0 0 0 0 0 37 10 0 % Q
% Arg: 0 0 0 0 10 0 10 10 0 0 0 0 0 37 10 % R
% Ser: 0 0 0 0 37 0 0 0 0 0 0 19 10 10 55 % S
% Thr: 10 0 19 0 0 0 0 46 10 10 0 0 0 10 0 % T
% Val: 0 0 0 10 0 0 0 0 10 0 0 0 10 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _